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Full text. Free. LIBRIS titelinformation: Role of the CD47/SIRPα-interaction in regulation of macrophage phagocytosis / Mattias Olsson. Gilead Sciences Inc. Gilead's Magrolimab, an Investigational Anti-CD47 Monoclonal Antibody, Receives FDA Breakthrough Therapy Designation Study of SHR2150 (TLR7 Agonist) in Combination With Chemotherapy Plus PD-1 or CD47 Antibody in Subjects With Unresectable/ Metastatic Solid Tumors.

Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). 2019-03-06 About InVivoMAb anti-mouse/human/rat CD47 (IAP). The MIAP410 monoclonal antibody reacts with mouse CD47 otherwise known as integrin-associated protein (IAP). CD47 is an approximately 50 kDa glycosylated five transmembrane protein that is ubiquitously expressed by both hematopoietic cells such as T and B lymphocytes, monocytes, platelets and erythrocytes and non-hematopoietic cells.

Cytoplasmic and membranous expression in several tissues. CD47 antibody Rabbit Polyclonal from Proteintech validated in Western Blot (WB ), Immunohistochemistry (IHC), Immunofluorescence (IF),Enzyme-linked 15 Sep 2020 CD47 is a tumor-associated antigen best known for its ability to bind counter- receptors on the surface of professional phagocytes as an CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis. Li-Chung Tsao,1 Erika J. Crosby,1 1 Sep 2020 Similar to cancer cells, all immune cells can upregulate their CD47 surface expression during infection.

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Cited in 1 publication(s). Blocking CD47 triggers the recognition and elimination of cancer cells by the innate immunity. There are three CD47 antagonists in phase I clinical trials, but their TSP-1和CD47的結合還會影響許多基本的細胞活動，包括凋亡、增殖、黏著與遷移，亦對血管新生和免疫有調節作用。信號調節蛋白α（SIRPα）[編輯].

However, the status of CD47 is a cell surface glycoprotein and is expressed on all normal cells in the body.
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This activates innate immunity, promoting cancer cell destruction by macrophages. It also activates CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 and signal-regulatory protein alpha .

30. 4.5 Signaling downstream of SIRPα in stromal cells upon activation by CD47.
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35 CD47 is important in the 维基百科，自由的百科全书. CD47 ，也称整联素关联蛋白（IAP），是在人体中由CD47基因编码的跨膜蛋白。. 它属于免疫球蛋白超家族，可以与整联蛋白、血小板反应素（TSP-1）以及信号调节蛋白α （SIRPα）相互作用。. CD-47作为一种可防止巨噬细胞吞噬的信号分子，具有作为某些癌症的治疗靶点的潜力，最新研究表明其也可能与肺纤维化有关。.

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CD47 is located on human chromosome 3q13. Immunogen CD47 molecule Application The SIRPα–CD47 axis was found to be highly species specific.

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